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The proportion of collagen to hydroxyapatite in bone determines the


A) thickness of the bone.
B) length of the bone.
C) strength of the bone.
D) ability of the bone to heal.
E) growth rate of bone.

F) All of the above
G) None of the above

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The connective tissue sheath of cartilage is called the ________.


A) matrix
B) chondrocyte
C) ligamentous cord
D) lacuna
E) perichondrium

F) B) and C)
G) A) and B)

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Which type of bone tissue is considered dense bone?


A) Spongy bone
B) Compact bone
C) Both "spongy bone" and "compact bone" are correct.

D) All of the above
E) B) and C)

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The application of pressure creates a slight electrical charge on osteoblasts.

A) True
B) False

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How does the integumentary system contribute to osteoporosis?


A) Lack of exposure to sunlight reduces vitamin D production and decreases calcium absorption.
B) Lack of exposure to sunlight increases calcitonin secretion leading to reduced calcium storage in the bones.
C) Estrogen produced in the dermis reduces calcium excretion in the kidneys.
D) Calcium ions released from the bones are excreted through sweat.
E) Decreased estrogen levels following menopause contribute to the disease.

F) B) and C)
G) A) and B)

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The proper sequence of events in bone repair is


A) callus formation, hematoma formation, callus ossification, remodeling of bone.
B) remodeling of bone, callus ossification, hematoma formation, callus formation.
C) hematoma formation, callus formation, callus ossification, remodeling of bone.
D) callus ossification, callus formation, remodeling of bone, hematoma formation.
E) hematoma formation, callus ossification, callus formation, remodeling of bone.

F) D) and E)
G) A) and B)

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What strengthens the attachment of the tendons or ligaments to bone?


A) Epiphysis
B) Sharpey fibers
C) Growth plate
D) Medullary cavity
E) Endosteum

F) B) and E)
G) C) and E)

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Osteoclasts have projections called ________ that cause bone reabsorption.


A) canaliculi
B) lacunae
C) ruffled borders
D) lamellae
E) crossroads

F) All of the above
G) B) and D)

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Which of the following statements about bone growth is TRUE?


A) Most growth in long bones results from interstitial growth.
B) Appositional bone growth results in increased bone length.
C) Endochondral growth in long bones occurs at the epiphyseal plate.
D) In the epiphyseal plate, osteoblasts degenerate to form chondrocytes.
E) Bones cannot grow by appositional growth.

F) A) and D)
G) None of the above

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Osteoclast activity is increased by ________.


A) parathyroid hormone
B) vitamin D
C) calcitonin
D) growth hormone
E) vitamin C

F) A) and C)
G) C) and E)

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Which chemical, ingested or synthesized by the body, is necessary for calcium absorption from the intestines?


A) Growth hormone
B) Sex hormones
C) Parathyroid hormone
D) Calcitonin
E) Vitamin D

F) D) and E)
G) A) and E)

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Spongy bone tissue


A) is very dense.
B) contains concentric lamellae.
C) contains interconnecting plates called trabeculae.
D) has many spaces and lacks osteocytes.
E) is the primary component of compact bone.

F) A) and E)
G) All of the above

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Lamellar bone


A) has its collagen fibers randomly oriented.
B) has a porous appearance.
C) is organized into thin sheets of tissue.
D) is very light in weight.
E) is not easily restructured.

F) A) and B)
G) B) and E)

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How does the reproductive system contribute to osteoporosis?


A) Lack of sex hormone production reduces vitamin D production and decreases calcium absorption.
B) Immune cells decrease in number after puberty and reduce bone repair.
C) Excessive smoking lowers estrogen levels, which increases bone loss.
D) Calcium ions released from the bones are necessary for gamete production.
E) Decreased estrogen levels following menopause contribute to the disease.

F) A) and E)
G) A) and B)

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The stem cells of osteoclasts are ________.


A) osteocytes
B) osteoclasts
C) chondrocytes
D) the same cells that give rise to monocytes
E) osteochondral progenitor cells

F) A) and D)
G) B) and D)

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Intramembranous ossification


A) forms the bones of the roof of the skull.
B) is the process that produces most of the skeletal system.
C) occurs when bones develop from cartilage models.
D) occurs when osteoblasts invade the spaces left by dying cartilage cells.
E) occurs on the outer surface of the membrane.

F) A) and B)
G) B) and E)

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Which of the following matrix molecules in cartilage tends to trap large quantities of water?


A) Collagen
B) Proteoglycan
C) Hyaluronic acid
D) Elastin
E) Chondrocytes

F) B) and E)
G) B) and D)

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Which of the following events occurs last in intramembranous ossification?


A) Osteoprogenitor cells become osteoblasts.
B) A membrane of delicate collagen fibers develops.
C) Spongy bone is formed.
D) Periosteum is formed.
E) Many tiny trabeculae of woven bone develop.

F) C) and E)
G) D) and E)

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Osteoclast activity would decrease when ________ levels are elevated.


A) parathyroid hormone
B) vitamin D
C) calcitonin
D) growth hormone
E) vitamin C

F) None of the above
G) A) and B)

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The compression (weight-bearing) strength of bone matrix is due to the presence of ________.


A) elastin fibers
B) collagenase
C) hydroxyapatite crystals
D) collagen fibers
E) bone marrow

F) A) and B)
G) A) and C)

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