Question 1

During latent herpes virus infections:

Accepted Answer

A)   the virus produces early proteins but not late proteins
B)   a latency associated transcript is produced
C)   no viral transcription occurs
D)   virus DNA is integrated into host DNA
E)   cell transcription machinery is silencedF) B) and C)
G) A) and B)

Question 2

What is a conditional lethal mutant? Give examples of two classes of conditional lethal mutants produced in T4 to demonstrate its assembly.

Accepted Answer

A conditional lethal mutant is a mutant ...

Question 3

How is the poliovirus genome replicated?

Accepted Answer

The poliovirus genome is single-stranded...

Question 4

AZT, a component in the drug mixture given to AIDS patients, is an inhibitor of __________.

Accepted Answer

A)   exit of endocytosed viruses
B)   endocytosis
C)   viral assembly
D)   reverse transcriptase
E)   viral polymeraseF) A) and E)
G) All of the above D

Question 5

Cyclophilin A is a host protein that:

Accepted Answer

A)   acts as a coreceptor for HIV
B)   facilitates HIV entry into the nucleus
C)   is incorporated in the HIV envelope
D)   inhibits HIV replication
E)   cuts the polyprotein into subunitsF) C) and E)
G) A) and B)

Question 6

Some people are resistant to HIV infection because they:

Accepted Answer

A)   lack CD4 receptors on their macrophages
B)   lack CCR5 receptors on their macrophages
C)   lack macrophages
D)   produce proteases that destroy HIV
E)   all of the aboveF) B) and D)
G) None of the above

Question 7

Mutations that allow viruses to replicate under one set of conditions but not under another set of conditions are known as __________ mutations.

Accepted Answer

A)   suppressor
B)   lethal
C)   conditional lethal
D)   silent
E)   nonsenseF) All of the above
G) C) and E)

Question 8

Worldwide, HIV infects one in how many adults?

Accepted Answer

A)   20
B)   50
C)   100
D)   500
E)   1,000F) A) and D)
G) A) and E)

Question 9

__________ primers, for nucleic acid synthesis, are common in many kinds of viruses.

Accepted Answer

A)   RNA
B)   DNA
C)   Polymerase
D)   Protein
E)   ProteaseF) C) and D)
G) A) and B)

Question 10

The __________ separation of early genes and late genes is common to the replicative cycles of many phages as well as viruses of eukaryotes.

Accepted Answer

A)   spatial
B)   physical
C)   temporal
D)   genetic
E)   lyticF) C) and E)
G) None of the above C

Question 11

Describe how priming is different for mRNA synthesis or template synthesis for viral progeny of influenza A virus.

Accepted Answer

To make (+) strand mRNA, the RNA-depende...

Question 12

Describe retroelements that are found in the human genome. How do endogenous retroviruses and retrotransposons differ?

Accepted Answer

Retroelements are remains of decaying retroviral genomes found throughout the human genome. Endogenous retroviruses contain all the genetic information of a retrovirus, but have lost the ability to produce virions. Retrotransposons retain only partial retroviral components, but are able to copy themselves into other genomic locations. The Alu family of sequences is an example of a retrotransposon. It is present in about a million copies per human genome and is responsible for some genetic diseases.

Question 13

Which of the following primers for nucleic acid replication is linked to the appropriate virus?

Accepted Answer

A)   M2 and poliovirus
B)   host caps and poliovirus
C)   Vpg and influenza virus
D)   virus tRNA and herpes virus
E)   host tRNA and HIVF) C) and E)
G) A) and C)

Question 14

Describe the two different times phage T4 uses virally produced lysozyme during its infection cycle.

Accepted Answer

The injector is composed of P5 proteins....

Question 15

RNA synthesis of influenza virus is primed by capped fragments of host mRNA, obtained by the "__________" method.

Accepted Answer

A)   telomerase
B)   rolling-circle
C)   endocytosis
D)   exocytosis
E)   cap-snatchingF) D) and E)
G) C) and D)

Question 16

In phage T4, the sheath plus the internal __________ comprise the tail.

Accepted Answer

A)   tube
B)   capsid
C)   envelope
D)   fibers
E)   nucleic acidF) C) and D)
G) D) and E)

Question 17

The cell membrane releases mature HSV-1 virions through __________.

Accepted Answer

A)   endocytosis
B)   exocytosis
C)   lysis
D)   budding
E)   slow releaseF) A) and D)
G) B) and E)

Question 18

Some polio virions may cross the blood-brain barrier to infect __________, causing paralysis.

Accepted Answer

A)   intestinal lining
B)   lymphoid tissue
C)   neurons
D)   muscles
E)   GALTF) B) and E)
G) None of the above

Question 19

Which of the following best describes the genome of influenza virus?

Accepted Answer

A)   negative strand segmented RNA
B)   positive strand segmented RNA
C)   negative strand single-piece RNA
D)   positive strand single-piece RNA
E)   double-stranded RNAF) A) and B)
G) A) and C)

Question 20

__________ primers are unique to viruses.

Accepted Answer

A)   mRNA
B)   Protein
C)   DNA
D)   tRNA
E)   rRNAF) B) and D)
G) C) and D)

Exam 11: Viral Molecular Biology

During latent herpes virus infections:

Correct Answer
verified

What is a conditional lethal mutant? Give examples of two classes of conditional lethal mutants produced in T4 to demonstrate its assembly.

Correct Answer
verified
A conditional lethal mutant is a mutant ...
View Answer

How is the poliovirus genome replicated?

Correct Answer
verified
The poliovirus genome is single-stranded...
View Answer

AZT, a component in the drug mixture given to AIDS patients, is an inhibitor of __________.

Correct Answer
verified
D

Cyclophilin A is a host protein that:

Correct Answer
verified

Some people are resistant to HIV infection because they:

Correct Answer
verified

Mutations that allow viruses to replicate under one set of conditions but not under another set of conditions are known as __________ mutations.

Correct Answer
verified

Worldwide, HIV infects one in how many adults?

Correct Answer
verified

__________ primers, for nucleic acid synthesis, are common in many kinds of viruses.

Correct Answer
verified

The __________ separation of early genes and late genes is common to the replicative cycles of many phages as well as viruses of eukaryotes.

Correct Answer
verified
C

Describe how priming is different for mRNA synthesis or template synthesis for viral progeny of influenza A virus.

Correct Answer
verified
To make (+) strand mRNA, the RNA-depende...
View Answer

Describe retroelements that are found in the human genome. How do endogenous retroviruses and retrotransposons differ?

Which of the following primers for nucleic acid replication is linked to the appropriate virus?

Correct Answer
verified

Describe the two different times phage T4 uses virally produced lysozyme during its infection cycle.

Correct Answer
verified
The injector is composed of P5 proteins....
View Answer

RNA synthesis of influenza virus is primed by capped fragments of host mRNA, obtained by the "__________" method.

Correct Answer
verified

In phage T4, the sheath plus the internal __________ comprise the tail.

Correct Answer
verified

The cell membrane releases mature HSV-1 virions through __________.

Correct Answer
verified

Some polio virions may cross the blood-brain barrier to infect __________, causing paralysis.

Correct Answer
verified

Which of the following best describes the genome of influenza virus?

Correct Answer
verified

__________ primers are unique to viruses.

Correct Answer
verified

Exam 11: Viral Molecular Biology

During latent herpes virus infections:

Correct AnswerverifiedShow Answer

What is a conditional lethal mutant? Give examples of two classes of conditional lethal mutants produced in T4 to demonstrate its assembly.

Correct AnswerverifiedA conditional lethal mutant is a mutant ...View AnswerShow Answer

How is the poliovirus genome replicated?

Correct AnswerverifiedThe poliovirus genome is single-stranded...View AnswerShow Answer

AZT, a component in the drug mixture given to AIDS patients, is an inhibitor of __________.

Correct AnswerverifiedD

Cyclophilin A is a host protein that:

Correct AnswerverifiedShow Answer

Some people are resistant to HIV infection because they:

Correct AnswerverifiedShow Answer

Mutations that allow viruses to replicate under one set of conditions but not under another set of conditions are known as __________ mutations.

Correct AnswerverifiedShow Answer

Worldwide, HIV infects one in how many adults?

Correct AnswerverifiedShow Answer

__________ primers, for nucleic acid synthesis, are common in many kinds of viruses.

Correct AnswerverifiedShow Answer

The __________ separation of early genes and late genes is common to the replicative cycles of many phages as well as viruses of eukaryotes.

Correct AnswerverifiedC

Describe how priming is different for mRNA synthesis or template synthesis for viral progeny of influenza A virus.

Correct AnswerverifiedTo make (+) strand mRNA, the RNA-depende...View AnswerShow Answer

Describe retroelements that are found in the human genome. How do endogenous retroviruses and retrotransposons differ?

Which of the following primers for nucleic acid replication is linked to the appropriate virus?

Correct AnswerverifiedShow Answer

Describe the two different times phage T4 uses virally produced lysozyme during its infection cycle.

Correct AnswerverifiedThe injector is composed of P5 proteins....View AnswerShow Answer

RNA synthesis of influenza virus is primed by capped fragments of host mRNA, obtained by the "__________" method.

Correct AnswerverifiedShow Answer

In phage T4, the sheath plus the internal __________ comprise the tail.

Correct AnswerverifiedShow Answer

The cell membrane releases mature HSV-1 virions through __________.

Correct AnswerverifiedShow Answer

Some polio virions may cross the blood-brain barrier to infect __________, causing paralysis.

Correct AnswerverifiedShow Answer

Which of the following best describes the genome of influenza virus?

Correct AnswerverifiedShow Answer

__________ primers are unique to viruses.

Correct AnswerverifiedShow Answer

Correct Answer
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Correct Answer
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A conditional lethal mutant is a mutant ...
View Answer

Correct Answer
verified
The poliovirus genome is single-stranded...
View Answer

Correct Answer
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D

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C

Correct Answer
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To make (+) strand mRNA, the RNA-depende...
View Answer

Correct Answer
verified

Correct Answer
verified
The injector is composed of P5 proteins....
View Answer

Correct Answer
verified

Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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