FiltersDone

Question type

Essay

Multiple Choice

Short Answer

True False

Matching

Exam 13: The Citric Acid Cycle

Show Answer

Share

---

All types

Filters

Study Flashcards

Question 1

Short Answer

Review LaterAdd Note

Review Later

Arsenic poisoning acts by inhibiting the citric acid cycle at the point of both pyruvate dehydrogenase and α-ketoglutarate dehydrogenase because it makes a stable adduct with the ________ groups of the dihydrolipoamide intermediate.

Correct Answer

verified

Show Answer

Question 2

Multiple Choice

Review LaterAdd Note

Review Later

Which of the following does NOT regulate flux through the citric acid cycle?

A) Substrate availability
B) The ratio of [NAD+]/[NADH]
C) Allosteric inhibition of isocitrate dehydrogenase by ADP
D) Inhibition of α-ketoglutarate dehydrogenase by succinyl CoA
E) Ca2+ activation of isocitrate dehydrogenase

F) A) and B)
G) A) and C)

Correct Answer

verified

Show Answer

Question 3

Short Answer

Review LaterAdd Note

The citric acid cycle can be considered both a ________ and anabolic pathway as it is used to oxidise acetyl CoA to carbon dioxide as well as to provide precursors for other ________ pathways.

Taking one mole of glucose through glycolysis and the citric acid cycle generates:

NAD+, coenzyme A, thiamine pyrophosphate, lipoic acid and FAD are all cofactors used in the reaction catalyzed by pyruvate dehydrogenase.

Acetyl CoA is a feed forward activator of the enzyme ________ ensuring sufficient oxaloacetate for the citric acid cycle to continue.

Oxaloacetate is replenished via the ________ in plants and bacteria.

The glyoxylate cycle in plants and bacteria can be used for net carbohydrate synthesis from fat because isocitrate lyase yields glyoxylate and ________ without the loss of two carbons as occurs in the citric acid cycle.

The citric acid cycle is classed as a reductive pathway as it produces reduced electron carriers.

Which of the following does NOT apply to the reaction catalyzed by the pyruvate dehydrogenase complex?

The two carbon atoms that are lost as CO2 in the third and fourth steps of the citric acid cycle are the same as the two carbon atoms of acetyl CoA because of the stereochemistry of the isocitrate dehydrogenase reaction.

The malate dehydrogenase reaction has a strongly positive standard free energy change but it proceeds in the direction of oxaloacetate because the concentration of ________ is maintained at exceedingly low levels.

Which of the following techniques can be used to quantify protein-protein interactions?

All of the enzymes of the citric acid cycle are located in the mitochondrion.

One substrate level phosphorylation occurs in the citric acid cycle in the reaction catalyzed by:

Which of the following enzymes catalyzes a reaction of the citric acid cycle that does NOT produce reduced electron carriers?

Transamination reactions can be used to provide intermediates for the citric acid cycle.